Title of article :
New Efficient Synthesis of 1-Hydroxymethylene-1,1-Bisphosphonate Monomethyl Esters
Author/Authors :
Migianu، Evelyne نويسنده , , Guenin، Erwann نويسنده , , Lecouvey، Marc نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2005
Abstract :
A new efficient procedure for the synthesis of 1-hydroxymethylene-1,1bisphosphonate monomethyl esters in three steps from acid chlorides is reported here.
Keywords :
1-hydroxymethylene-1,1-bisphosphonates , (alpha)-ketophosphonates , bis(silylated) phosphate , Arbuzov reaction
