Title of article
Cytotoxic sesquiterpenes from luminescent mushroom Neonothopanus nambi
Author/Authors
Somdej Kanokmedhakul، نويسنده , , Ratsami Lekphrom، نويسنده , , Kwanjai Kanokmedhakul، نويسنده , , Chariya Hahnvajanawong، نويسنده , , Sureeporn Bua-art، نويسنده , , Weerasak Saksirirat، نويسنده , , Samran Prabpai، نويسنده , , Palangpon Kongsaeree، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2012
Pages
6
From page
8261
To page
8266
Abstract
Four new aristolane sesquiterpenes named nambinones A–C (1–3) and 1-epi-nambinone B (4), a new sesquiterpene, nambinone D (5), a known compound, aurisin A (6) as well as a new dimeric sesquiterpene, aurisin K (7), were isolated from two isolates of luminescent mushroom, Neonothopanus nambi, PW1 and PW2. These structures were established on the basis of spectroscopic evidence. The relative configuration of 6 was determined by X-ray crystallographic analysis. Compounds 6 and 7 exhibited antimalarial activity against Plasmodium falciparum and antimycobacterial activity against Mycobacterium tuberculosis. Compounds 3, 6, and 7 showed cytotoxicity against NCI-H187 cancer cell lines. In addition, 6 and 7 showed cytotoxicity against the cholangiocarcinoma cell lines.
Keywords
Cytotoxicity , Neonothopanus nambi , Luminescent mushroom , Aristolane sesquiterpenes , Nambinone , Aurisin , antimalarial
Journal title
Tetrahedron
Serial Year
2012
Journal title
Tetrahedron
Record number
1104981
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