Title of article
Jatrophane diterpenoids with multidrug resistance-modulating activity from Euphorbia mongolica Prokh.
Author/Authors
Dora Rédei، نويسنده , , Peter Forgo، نويسنده , , Joseph Molnar، نويسنده , , P?l Szab?، نويسنده , , Tumur Zorig، نويسنده , , Judit Hohmann، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2012
Pages
5
From page
8403
To page
8407
Abstract
Four novel (1–4) and one known (5) diterpene polyesters with the jatrophane skeleton were isolated from a methanol extract of the aerial parts of the East Asian weed Euphorbia mongolica Prokh. The isolated compounds were characterized structurally and evaluated for multidrug resistance (MDR) reversing activity on human MDR gene-transfected L5178 mouse lymphoma cells; all these compounds were found to modulate the intracellular drug accumulation. The results highlighted some aspects of the structural requirements of jatrophane diterpenes as MDR modulators.
Keywords
Euphorbiaceae , Euphorbia mongolica Prokh. , Jatrophane , Multidrug resistance , diterpene
Journal title
Tetrahedron
Serial Year
2012
Journal title
Tetrahedron
Record number
1104997
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