Title of article
First Stereoselective Synthesis of the C(1)-C(13) Fragment of Dolabelides Using Ruthenium-SYNPHOS(registered)-Catalyzed Asymmetric Hydrogenation Reactions
Author/Authors
Genet، Jean-Pierre نويسنده , , Roux، Remi Le نويسنده , , Desroy، Nicolas نويسنده , , Phansavath، Phannarath نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
-428
From page
429
To page
0
Abstract
The first stereocontrolled synthesis of the C(1)-C(13) fragment of cytotoxic macrolides dolabelides is reported. The C(3), C(7), C(9) and C(11) hydroxyl-bearing stereocenters were installed using ruthenium-mediated asymmetric hydrogenation reactions of the adequate (beta)-keto esters and (beta)hydroxy ketone.
Keywords
hydrogenation , Asymmetric catalysis , Ruthenium , natural products , total synthesis
Journal title
Synlett
Serial Year
2005
Journal title
Synlett
Record number
110501
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