Author/Authors :
Carole Barbey، نويسنده , , Radia Bouasla، نويسنده , , Malika Berredjem، نويسنده , , Nathalie Dupont، نويسنده , , Pascal Retailleau، نويسنده , , Nour-Eddine Aouf، نويسنده , , Marc Lecouvey، نويسنده ,
Abstract :
The synthesis of new series of oxazolidinones having sulfonamide moieties is described. These compounds are synthesized in good yield starting prochiral 1,3-dichloro-2-propanol and chlorosulfonyl isocyanate. This strategy involves the formation of carboxylsulfamide by carbamoylation–sulfamoylation reaction followed by intermolecular cyclization. In order to determine the enantioselectivity during the cyclization step, X-ray studies of products are performed.
