Title of article
Direct Formation of Synthetically Useful Silyl-Protected Aldol Adducts via the Asymmetric Reductive Aldol Reaction
Author/Authors
Fuller، Nathan O. نويسنده , , Morken، James P. نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
-1458
From page
1459
To page
0
Abstract
Examination of different silane reducing agents in the reductive aldol reaction revealed that Me2i-PrSiH is highly selective for formation of the silylated aldol adduct versus the derived acylated adduct. This silicon group provides more robust protection for the product (beta)-hydroxyl group than the diethylmethylsilyl group, which was employed previously.
Keywords
asymmetric synthesis , Asymmetric Catalysis , protecting groups , hydrosilylations , aldol reactions
Journal title
Synlett
Serial Year
2005
Journal title
Synlett
Record number
110517
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