Selective nitrile oxide dipolar cycloaddition for the synthesis of highly functionalized β-aminocyclohexanecarboxylate stereoisomers

Highly functionalized β-aminocyclohexanecarboxylate regio- and stereoisomers were synthesized from a bicyclic β-lactam by successive regioselective iodolactonization, stereo- and regioselective nitrile oxide cycloaddition, lactone ring-opening and isoxazoline ring-opening.