Title of article
Pyrazole-3/5-carboxylic acids from 3/5-trifluoromethyl NH-pyrazoles
Author/Authors
Mikhail S. Ermolenko، نويسنده , , Sandrine Guillou، نويسنده , , Yves L. Janin، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2013
Pages
7
From page
257
To page
263
Abstract
We report here the transformation of 3/5-trifluoromethylpyrazoles derivative into the corresponding NH-pyrazole-3/5-carboxylic acids. Moreover, from 4- or 5-iodinated-3/5-trifluoromethylpyrazoles building blocks and the use of Suzuki–Miyaura or Negishi reactions followed by the trifluoromethyl hydrolysis, we illustrate short and original accesses to many series of NH-pyrazole-3/5-carboxylic acids otherwise difficult to prepare.
Keywords
Building blocks , 3/5-Trifluoromethylpyrazoles , Pyrazole-3/5-carboxylic acids , Cross-coupling , Palladium catalysis
Journal title
Tetrahedron
Serial Year
2013
Journal title
Tetrahedron
Record number
1105302
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