Title of article
Cytotoxic sesquiterpenoids from Sarcandra glabra
Author/Authors
Hong-Gang Ni، نويسنده , , Hua Zhang، نويسنده , , Hong-Chun Liu، نويسنده , , Sheng-Ping Yang، نويسنده , , Mei-Yu Geng، نويسنده , , Jian-Min Yue، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2013
Pages
6
From page
564
To page
569
Abstract
Five new sesquiterpenoid dimers, sarcandrolides F−J (1−5), three new sesquiterpenoid monomers (6−8), and 14 known sesquiterpenoids, were isolated from the whole plants of Sarcandra glabra. The absolute configurations of compounds 1−5 were established by the CD exciton chirality method. Compound 1 represents the first example of a lindenane-type sesquiterpenoid dimer bearing a hydroperoxy group at C-5. Compounds 1 and 3 exhibited cytotoxicity against the HL-60 cell line with IC50 values of 0.03 and 1.2 μM, respectively.
Keywords
Sarcandra glabra , Sarcandrolides F?J , Sarcandralactones C?E , Sesquiterpenoid dimers , CD exciton chirality , Structural elucidation
Journal title
Tetrahedron
Serial Year
2013
Journal title
Tetrahedron
Record number
1105340
Link To Document