Title of article
A Versatile Approach to Protected (4S,5R)-4-Hydroxy-5(-hydroxyalkyl)-2-pyrrolidinones
Author/Authors
Zhou، Xiang نويسنده , , Huang، Pei-Qiang نويسنده ,
Pages
-1234
From page
1235
To page
0
Abstract
Starting from (S)-N,O-dibenzylmalimide (7), a versatile four-step approach to (4S,5R)-Nbenzyl-4-benzyloxy-5-(-hydroxyalkyl)-2-pyrrolidinones 9 is reported. The method consists of Grignard reagent addition, p-toluenesulfonic acid monohydrate-mediated dehydration, one-pot epoxidation-methanol ring-opening reaction and reductive demethoxylation. 2Pyrrolidinones 9 were obtained with excellent trans-diastereoselectivity in the pyrrolidinone ring and low diastereoselectivity at the carbinol center
Keywords
cascade reactions , quinolizidines , indolizidines , pyrrolizidines
Journal title
Astroparticle Physics
Record number
110557
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