Title of article
Mitsunobu cyclodehydration of N-pivaloyl-2-aminophenethyl alcohol for asymmetric synthesis of trans-2,3-disubstituted indolines
Author/Authors
Kyoung Hee Kang، نويسنده , , Yelim Kim، نويسنده , , Chan Im، نويسنده , , Yong-Sun Park and Sang Joon Kim، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2013
Pages
8
From page
2542
To page
2549
Abstract
Highly enantioenriched trans-2,3-disubstituted indolines have been prepared by Mitsunobu cyclodehydration of the amino alcohols obtained from (−)- or (+)-sparteine-mediated lithiation–substitution of ortho-alkyl substituted N-pivaloylanilines. Optimized cyclodehydration conditions are described, from which the combination of DEAD and PBu3 in CH3CN provides the best results.
Journal title
Tetrahedron
Serial Year
2013
Journal title
Tetrahedron
Record number
1105584
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