Title of article :
Suzuki coupling based synthesis and in vitro cytotoxic evaluation of Fingolimod and analogues
Author/Authors :
Tie-Wen Mei، نويسنده , , Yu Luo، نويسنده , , Xiang-Jun Feng، نويسنده , , Wei Lu، نويسنده , , Bo Yang، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2013
Abstract :
A concise synthesis of Fingolimod (FTY720) and its analogues was described. The key step involved Suzuki coupling of arylboronate 11 with different bromides. In addition, the newly synthesized Fingolimod analogues (5a–i and 6a–c) were evaluated for their in vitro cytotoxicity against SMCC-7721 and HL-60 cell lines. The preliminary SAR was discussed.
Keywords :
concise synthesis , Suzuki coupling , Key step , Cytotoxicity
Journal title :
Tetrahedron
Journal title :
Tetrahedron
