Author/Authors :
Wataru Fujii، نويسنده , , Kazuya Toda، نويسنده , , Koichiro Kawaguchi، نويسنده , , Sei-ichi Kawahara، نويسنده , , Miyuki Katoh، نويسنده , , Yasunao Hattori، نويسنده , , Hiroshi Fujii، نويسنده , , Hidefumi Makabe، نويسنده ,
Abstract :
Total synthesis of prodelphinidin B3 and C2 have been accomplished. The key step is Lewis acid-mediated equimolar condensations between a catechin and/or gallocatechin nucleophile and a gallocatechin electrophile. The antitumor effects of synthetic prodelphidin B3 and C2 against PC-3 prostate cancer cell lines have been investigated. Both compounds showed significant antitumor effects. Their activity was almost the same as that of EGCG, a known antitumor agent.
Keywords :
Polyphenols , Synthesis , Natural product , anticancer agents
