Title of article
A stereocontrolled route to d-ribo-phytosphingosine and sphinganine from an achiral secondary homoallylic alcohol using Sharpless kinetic resolution
Author/Authors
Thongam Joymati Devi، نويسنده , , Bishwajit Saikia، نويسنده , , Nabin C. Barua، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2013
Pages
6
From page
3817
To page
3822
Abstract
A facile and efficient enantioselective route for the synthesis of d-ribo-phytosphingosine (1a) and sphinganine (1b) has been developed employing commercially available and cheap starting material trans-cinnamaldehyde 2. The synthetic strategy features the Sharpless kinetic resolution, regioselective epoxide opening and Wittig olefination as the key steps.
Keywords
Regioselective , sphingolipid , Phytosphingosine , Sphinganine , apoptosis
Journal title
Tetrahedron
Serial Year
2013
Journal title
Tetrahedron
Record number
1105730
Link To Document