Title of article :
Development of simple firefly luciferin analogs emitting blue, green, red, and near-infrared biological window light
Author/Authors :
Satoshi Iwano، نويسنده , , Rika Obata، نويسنده , , Chihiro Miura، نويسنده , , Masahiro Kiyama، نويسنده , , Kazutoshi Hama، نويسنده , , Mitsuhiro Nakamura، نويسنده , , Yoshiharu Amano، نويسنده , , Satoshi Kojima، نويسنده , , By TAKASHI HIRANO، نويسنده , , Shojiro Maki، نويسنده , , Haruki Niwa، نويسنده ,
Abstract :
Simple firefly luciferin analogs emitting blue, green, and red light were developed. The longest emission maximum was observed at 675 nm, which belongs to the NIR biological window (650–900 nm), useful for deep site bioimaging of living animals. The analogs showed a slow rise of emission intensity compared with the rapid emission of natural luciferin. The light emission of the adenylated analogs was strongly enhanced compared with those of analogs themselves.
Keywords :
Firefly , Near-infrared , Luciferin analog , Biological window , bioluminescence
