Title of article
Assembly of N,N-disubstituted-N′-arylureas via a copper-catalyzed one-pot three-component reaction of aryl bromides, potassium cyanate, and secondary amines
Author/Authors
Hongfei Yin، نويسنده , , Bing Chen، نويسنده , , Xiaojing Zhang، نويسنده , , Xinye Yang، نويسنده , , Yihua Zhang، نويسنده , , Yongwen Jiang، نويسنده , , Dawei Ma، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2013
Pages
5
From page
5326
To page
5330
Abstract
A three-component reaction of aryl bromides, potassium cyanate, and secondary amines takes place at 110 °C in MeCN under the catalysis of Cu2O and 2-(2,6-dimethylphenylamino)-2-oxoacetic acid potassium salt, giving N,N-disubstituted-N′-arylureas in good to excellent yields. A number of functionalized aryl bromides and secondary amines were compatible with these conditions, and thereby providing a facile method for diverse synthesis of trisubstituted ureas.
Keywords
Palladium , ?-Allyl complex , Masked acyl cyanide , Aziridine
Journal title
Tetrahedron
Serial Year
2013
Journal title
Tetrahedron
Record number
1105910
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