Title of article :
Reductive Alkylation of Aromatic Amines with Enol Ethers
Author/Authors :
Reddy، T. Jagadeeswar نويسنده , , Leclair، Michael نويسنده , , Proulx، Melanie نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2005
Abstract :
Reductive alkylation of aromatic amines with 2-methoxypropene using 1.0 equivalent of HOAc and NaBH(OAc)3 in 1,2dichloroethane (DCE) at room temperature furnished N-isopropyl amines in 50-98% yields. This method was successfully extended to trimethylsilyl enol ethers. The mild reaction conditions provide a new alternative procedure for the reductive amination of electron deficient aromatic amines.
Keywords :
reductive alkylation , aromatic amines , 2-methoxypropene , trimethylsilylenol ethers , sodium triacetoxyborohydride
