Title of article
Ligand-accelerating low-loading copper-catalyzed effective synthesis of (E)-1,3-enynes by coupling between vinyl halides and alkynes performed in water
Author/Authors
Peng Sun، نويسنده , , Hong Yan، نويسنده , , Linhua Lu، نويسنده , , Defu Liu، نويسنده , , Guangwei Rong، نويسنده , , Jincheng Mao، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2013
Pages
6
From page
6969
To page
6974
Abstract
The useful conjugated enynes could be easily prepared via low-loading (0.0001 mol %) copper-catalyzed coupling between vinyl halides and terminal alkynes. It is noteworthy that this reaction could be preformed in water without using any co-solvents and the desired 1,3-enynes could be obtained with good yields. In the catalytic reaction, ligand-acceleration effect was markable.
Keywords
Sonogashira coupling , Alkynyl carboxylic acid , aryl halide , terminal alkynes , Low-loading
Journal title
Tetrahedron
Serial Year
2013
Journal title
Tetrahedron
Record number
1106104
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