Title of article
Artabolide, a novel polar auxin transport inhibitor isolated from Artemisia absinthium
Author/Authors
Tsukasa Arai، نويسنده , , Yuta Toda، نويسنده , , Kiyotaka Kato، نويسنده , , Junichi Ueda ، Kensuke Miyamoto ، نويسنده , , Tsuyoshi Hasegawa، نويسنده , , Kosumi Yamada، نويسنده , , Junichi Ueda، نويسنده , , Koji Hasegawa، نويسنده , , Tsuyoshi Inoue، نويسنده , , Hideyuki Shigemori، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2013
Pages
5
From page
7001
To page
7005
Abstract
A new sesquiterpene with an α-methylene-γ-lactone moiety, artabolide (1), and three known derivatives 2–4 were isolated from Artemisia absinthium. The structure of 1 was elucidated by 1D and 2D NMR analyses, and the absolute configuration was determined using the modified Mosherʹs method and X-ray crystal structural analysis. Approximately 2.5 μg/plant treatment of artabolide (1) exhibited ca. 50% inhibition of polar auxin transport in radish hypocotyls, while 2–4 showed no significant inhibitory activity. Therefore, these results support the importance of the α-methylene-γ-lactone moiety for the inhibition of polar auxin transport.
Keywords
?-Methylene-?-lactone , Polar auxin transport inhibitor , Modified Mosherיs method , Artabolide , X-ray crystal structure analysis
Journal title
Tetrahedron
Serial Year
2013
Journal title
Tetrahedron
Record number
1106109
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