Title of article
Regioselective ring-opening reaction of 2-trifluoromethyl-N-tosylaziridine with some nucleophiles under basic conditions
Author/Authors
Yui Takehiro، نويسنده , , Kensuke Hirotaki، نويسنده , , Chihomi Takeshita، نويسنده , , Hiroshi Furuno، نويسنده , , Takeshi Hanamoto، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2013
Pages
7
From page
7448
To page
7454
Abstract
The ring-opening reaction of 2-trifluoromethyl-N-tosylaziridine with a variety of heteroatom- and carbon-centered nucleophiles was achieved under basic conditions in good to high yield with excellent regioselectivity. These findings enabled an easy access to useful α-trifluoromethyl-N-tosylmethylamine derivatives, such as 1,2-aminoalcohol, 1,2-diamine, 1,2-aminothiol, and distant secondary amine.
Keywords
trifluoromethyl group , ring-opening reaction , CF3-Building block , Aziridine
Journal title
Tetrahedron
Serial Year
2013
Journal title
Tetrahedron
Record number
1106166
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