Author/Authors :
Daishiro Minato، نويسنده , , Bozhi Li، نويسنده , , Dejun Zhou، نويسنده , , Yasumi Shigeta، نويسنده , , Naoki Toyooka، نويسنده , , Hiroaki Sakurai، نويسنده , , Kenji Sugimoto، نويسنده , , Hideo Nemoto، نويسنده , , Yuji Matsuya، نويسنده ,
Abstract :
Simplified des-AB-type aglycone of antitumor steroidal saponin OSW-1 was concisely prepared starting from readily available Hajos ketone. We further completed the synthesis of des-AB-OSW-1 analogue by the installation of the disaccharide moiety into the des-AB aglycone, and evaluated its antitumor activity. The results indicated that a truncated aglycone drug design strategy based on OSW-1 would be a promising approach for the development of novel antitumor agents.
Keywords :
OSW-1 , Organic synthesis , drug design , Aglycone , Antitumor agents
