Title of article
Palladium-Catalyzed Cross-Coupling of Alkynylzincs with Allylic Electrophiles: An Efficient and Selective Synthesis of Stereo- and Regio-Defined 1,4-Enynes
Author/Authors
Negishi، Ei-ichi نويسنده , , Qian، Mingxing نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
-1788
From page
1789
To page
0
Abstract
Clean and high-yielding cross-coupling of alkynylzincs with allylic chlorides, bromides, or acetates exhibiting 98% regio- and stereoselectivity can be achieved by using 1 mol% of Pd(DPEphos)Cl2 and either 1:1 THF-DMF or pure DMF. This reaction provides a satisfactory route to 1,4-enynes via Pd-catalyzed alkynyl-allyl coupling.
Keywords
Pd-catalyzed alkynyl-allyl coupling , 1,4-enynes , alkynylzincs , allylic electrophiles , Pd(DPEphos)Cl2
Journal title
Synlett
Serial Year
2005
Journal title
Synlett
Record number
110628
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