Title of article
Stereoselective total synthesis of (−)-brevisamide
Author/Authors
J.S. Yadav، نويسنده , , N. Mallikarjuna Reddy، نويسنده , , Md. Ataur Rahman، نويسنده , , A.R Prasad، نويسنده , , B.V. Subba Reddy، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2013
Pages
8
From page
8618
To page
8625
Abstract
The stereoselective total synthesis of (−)-brevisamide, a novel marine cyclic ether alkaloid isolated from dinoflagellate karenia brevis is described. The key steps involved in this synthesis are the Sharpless asymmetric epoxidation and regioselective ring opening of chiral epoxide by Gilmanʹs reagent. The tetrahydropyran core has been constructed by an intramolecular SN2 cyclisation.
Keywords
TEMPO-BIAB oxidation , SN2 cyclisation , Horner–Wadsworth–Emmons reaction , Gilmanיs reaction , Sharpless asymmetric epoxidation
Journal title
Tetrahedron
Serial Year
2013
Journal title
Tetrahedron
Record number
1106301
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