Author/Authors :
Liang-Wen Qi، نويسنده , , Liang-liang Wang، نويسنده , , Lin Peng، نويسنده , , Li-Na Jia، نويسنده , , Fang Tian، نويسنده , , Xiao-Ying Xu، نويسنده , , Li-Xin Wang، نويسنده ,
Abstract :
Organocatalytic Michael–aldol–dehydration domino reaction of 3-(1-hydroxyethylidene)benzofuran-2(3H)-ones and enones catalyzed by Cinchona-based primary amine has been developed. The desired chiral spirocyclic benzofuranones were obtained in excellent stereoselectivities (dr>20:1 and up to 96% ee) and moderate to excellent yields (up to 98%).
Keywords :
Organocatalysis , Asymmetric catalysis , domino reaction , Benzofuranone , Spirocyclic compound
