Author/Authors :
Giuliana Righi، نويسنده , , Giorgio Scotti، نويسنده , , Francesco Caruso، نويسنده , , Miriam Rossi، نويسنده , , Francesco Mecozzi، نويسنده , , Roberto Antonioletti، نويسنده , , Romina Pelagalli، نويسنده ,
Abstract :
The Lewis acid-catalyzed regioselective azidolysis of 2,3-three membered heterocyclic amines has been investigated. The results obtained demonstrated that using TMSN3 as a source of azide, the appropriate choice of Lewis acid allowed to obtain different regio- and stereocontrolled precursors of aminoalcoholic and triaminic sequences. Considering the occurrence of these moieties in the structure of many biologically active compounds, the present methodologies could represent a powerful tool in organic synthesis for the preparation of interesting molecules.
