Author/Authors :
Witold G?adkowski، نويسنده , , Andrzej Skrobiszewski، نويسنده , , Marcelina Mazur، نويسنده , , Monika Siepka، نويسنده , , Aleksandra Pawlak، نويسنده , , Bozena Obminska-Mrukowicz، نويسنده , , Agata Bia?o?ska، نويسنده , , Dominik Poradowski، نويسنده , , Angelika Drynda، نويسنده , , Mariusz Urbaniak، نويسنده ,
Abstract :
A series of 20 novel racemic iodo-, bromo- and chlorolactones, possessing β-phenyl-γ-lactone or β-phenyl-δ-lactone framework, were synthesized from commercially available aromatic aldehydes in convenient five-step syntheses. Some of them showed noticeable cytotoxic effect against two cancer lines, Jurkat (human leukaemia) and D17 (canine osteosarcoma). The highest activity, comparable with carboplatin, was observed for cis-5-(1-iodoethyl)-4-(4′-isopropylphenyl)dihydrofuran-2-one against Jurkat cell line.
Keywords :
Lactones , Aromatic ring , Cytotoxic activity , Halolactonization
