Title of article :
Asymmetric Alkylation of a tert-Butyl Benzophenone Schiff Base Derivative in Water
Author/Authors :
Li، Le Wei نويسنده , , Zhang، Zhengpu نويسنده , , Zhu، Xiaoxia نويسنده , , Popa، A. نويسنده , , Wang، Shanwei نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2005
Abstract :
The asymmetric alkylation of a tert-butyl benzophenone Schiff base derivative in water has been successfully carried out in a ‘reversed-phase reaction’. The effects of chiral phase-transfer catalysts (PTCs), electrophiles, and reaction conditions (temperature, concentration, and the ratio of reagents, etc.) were investigated. Under the optimized conditions high chemical yield (99%) and good ee (up to 87%) were obtained.
Keywords :
cinchona alkoloids , amino acids , alkylations , phase-transfer , Asymmetric Catalysis
