A one-pot synthesis of isoindolin-1-imine derivatives

A one-pot procedure was developed for the synthesis of isoindolin-1-imine derivatives by a simple three-component condensation of 2-cyanobenzaldhyde, ammonium acetate, and 4-hyroxycoumarin derivatives or 1,3-dicarbonyl compounds or 4-hydroxyquinolin-2(1H)-one in ethanol under reflux for 20–60 min with excellent yields. The advantages of this procedure are operational simplicity, excellent yields, and short reactive time, without catalyst, easy workup, and green environmental impact.