Title of article :
A Practical Synthetic Pathway to Polysubstituted Tetrahydropyridines via Multicomponent Reactions Catalyzed by BF3·OEt2
Author/Authors :
Feng، Xiaoming نويسنده , , Xiao، Daijun نويسنده , , Wang، Lijia نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2005
Abstract :
BF3·OEt2-catalyzed solvent-free synthesis of tetrahydropyridines has been developed through a one-pot multicomponent reaction of aldehydes, anilines and Brassard’s diene under mild reaction conditions. A gram scale synthesis was achieved in 62% yield. A two-step condensation pathway (firstly aldol and then aza Diels-Alder condensation) was proposed.
Keywords :
multicomponent reaction , aldol condensation , aza Diels-Alder condensation , tetrahydropyridine , BF3·OEt2
