Title of article
Convenient and Regioselective Synthesis of Nucleoside Phosphoramidate Monoesters
Author/Authors
Fu، Hua نويسنده , , Zhao، Yufen نويسنده , , Zhu، Jigang نويسنده , , Jiang، Yuyang نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
-1926
From page
1927
To page
0
Abstract
We have developed a convenient and efficient method for the synthesis of nucleoside phosphoramidate monoesters. This step-wise synthesis, consisting of an ester exchange, reaction of the 5’-OH of nucleosides with fluorenylmethyl aryl phosphite, and an Atherton-Todd reaction, gave fluorenylmethyl nucleoside 5’-phosphoramidates; final removal of the fluorenylmethyl group yielded the desired target products in good yields.
Keywords
nucleoside , phosphoramidate , ester-exchange , diphenyl phosphite , Atherton-Todd reaction
Journal title
Synlett
Serial Year
2005
Journal title
Synlett
Record number
110678
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