Efficient and Stereoselective Synthesis of Precursors for Epoxypolyene Cyclizations via Allylic Substitutions

A catalytic and highly stereoselective approach to precursors for epoxypolyene cyclizations based on copper-catalyzed allylic substitutions is described. The method allows introduction of various aromatic, benzyl, and alkyl groups without affecting epoxides. The compounds obtained are valuable starting materials for the synthesis of natural products and biologically active substances.