• Title of article

    Studies towards the Synthesis of Rapamycin: Regiocontrol in the Addition of Carbanions to Enantiomerically Pure Epoxides and the Formation of a Highly Substituted Tetrahydrofuran

  • Author/Authors

    Oh، Kyungsoo نويسنده , , Cheshire، David نويسنده , , Parsons، Philip J. نويسنده ,

  • Issue Information
    روزنامه با شماره پیاپی سال 2005
  • Pages
    -162
  • From page
    163
  • To page
    0
  • Abstract
    Reaction of trimethylaluminium, dimethyllithium cuprate and lithium tetramethylaluminate with the homochiral epoxide 8 has been studied. Intermolecular epoxide ring-opening was observed with dimethyllithium cuprate and lithium tetramethylaluminate, but acetal ring-opening followed by intramolecular epoxide ring-opening was observed with trimethylaluminium.
  • Keywords
    substituted tetrahydrofuran , rapamycin , epoxide-opening , lithium tetramethylaluminate , trimethylaluminium
  • Journal title
    Synlett
  • Serial Year
    2005
  • Journal title
    Synlett
  • Record number

    110727

    • Link To Document
    https://search.isc.ac/dl/search/defaultta.aspx?DTC=10&DC=110727