Author/Authors :
Gatilov، Yuri V. نويسنده , , Trukhin، Dmitry V. نويسنده , , Bagryanskaya، Irina Yu. نويسنده , , Mikhalina، Tatiana V. نويسنده , , Rogozhnikova، Olga Yu. نويسنده , , Troitskaya، Tatiana I. نويسنده , , Tormyshev، Victor M. نويسنده ,
Abstract :
Cbz-protected 2-(1-aminoalkyl)oxazole-5-carboxylates are readily obtainable by a two-step enantioselective sequence involving reaction of benzyloxycarbonyl protected amino acids with (alpha)-chloro-(beta)-ketoesters and subsequent cyclization of the resulting acyloxyketones to required oxazoles upon treatment with neat ammonium trifluoacetate.
