Title of article :
A Regioselective Route to 5- and 6-Azaindoles
Author/Authors :
Lomberget، Thierry نويسنده , , Radix، Sylvie نويسنده , , Barret، Roland نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2005
Abstract :
The synthesis of 4,7-dimethoxy 5- and 6-azaindoles, a structural unit that is present in recently developed anti-HIV-1 agents, was achieved in a regioselective manner. The developed strategy is based on the appropriate choice of a protecting group during a lithium-mediated formylation step, followed by thermal cyclization of azidoacrylates.
Keywords :
pyridines , Metalations , 5- and 6-azaindoles , Azides , regioselectivity
