Title of article
1,2-syn-Selective and Enantioselective Michael Reactions of Acyclic Enones with a Propionate-Derived Nucleophile Catalyzed by Oxazaborolidinone
Author/Authors
Harada، Toshiro نويسنده , , Yamauchi، Toyonao نويسنده , , Adachi، Shinya نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
-2150
From page
2151
To page
0
Abstract
allo-Threonine-derived oxazaborolidinone 1b is demonstrated to be an effective catalyst for the stereoselective Michael reaction of simple acyclic enones with propionate-derived silyl ketene acetals. The reaction affords the corresponding Michael adducts with two contiguous asymmetric centers with high syn selectivity and enantioselectivity.
Keywords
asymmetric , boron , catalysis , Michael additions , Lewis acids
Journal title
Synlett
Serial Year
2005
Journal title
Synlett
Record number
110780
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