Title of article
Exploiting Planar Chirality for the Generation of (alpha)-Ferrocenyl Stereogenic Centres
Author/Authors
Roca، Francesc X. نويسنده , , Richards، Christopher J. نويسنده , , Taylor، Caroline J. نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
-2158
From page
2159
To page
0
Abstract
Addition of Grignard reagents R1MgBr (R1 = Me, Et, i-Pr, t-Bu, Ph) to 2-bromo- and 2trimethylsilylferrocenecarboxaldehyde proceeded, in most cases, with high diastereoselectivity to generate (alpha)-ferrocenyl alcohols of S*,pS* configuration. Following conversion into their corresponding acetates, reaction with dimethylamine provided (alpha)-ferrocenyl amines with retention of configuration (R1 = Me, Et, Ph).
Keywords
Metallocenes , Ligands , Grignard reactions , asymmetric synthesis , Stereoselectivity
Journal title
Synlett
Serial Year
2005
Journal title
Synlett
Record number
110784
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