Title of article
Design and Synthesis of Novel 20-epi Analogues of Calcitriol with Restricted Side Chain Conformation
Author/Authors
Fernandez-Molina، J. Carlos نويسنده , , Gomez، Generosa نويسنده , , Lago، Carmen نويسنده , , Moman، Edelmiro نويسنده , , Fall، Yagamare نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
-2162
From page
2163
To page
0
Abstract
The design and efficient preparation of two 20-epi analogues of calcitriol with restricted side chain conformation is described. The formation of the tetrahydropyran ring was achieved via zinc chloride mediated etherification of alcohols. Docking experiments show that these novel analogues could be interesting synthetic targets.
Keywords
vitamin D , analogues , Synthesis , nitriles , diols , drugs
Journal title
Synlett
Serial Year
2005
Journal title
Synlett
Record number
110786
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