Polymer-Supported IBX-Amide Reagents: Significant Role of Spacer and Additive in Alcohol Oxidation

We found that the spacer and additive play a significant role in the oxidation of alkyl alcohols using polymer-supported IBXamide reagents. The introduction of the spacer between the polymer support and IBX-amide group improved the initial conversion rate (up to 60% conversion). Furthermore, various alcohol compounds, when reacted with IBX-amide resin in the presence of BF3·OEt2, were effectively converted into the corresponding aldehydes or ketones within 5-30 minutes in high purities (>94%) at room temperature.