Title of article :
Asymmetric Synthesis of 4’-Quaternary 2’-Deoxy-3’-epi-(beta)-CNucleosides
Author/Authors :
Enders، Dieter نويسنده , , Ridder، Andre نويسنده , , Hieronymi، Antje نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2005
Abstract :
An efficient diastereo- and enantioselective synthesis of 4’-quaternary 2’deoxy-3’-epi-(beta)-C-nucleosides is described employing the RAMP-hydrazone methodology to establish the first stereocentre. Further key steps include diastereoselective nucleophilic 1,2-additions with Grignard and organocerium reagents.
Keywords :
asymmetric synthesis , nucleoside analogues , hydrazones , organocerium reagents , diastereoselective reduction
