Title of article
Solid-Support Synthesis of Natural Product-like Compounds Derived from D-(-)-Ribose
Author/Authors
Marzinzik، Andreas L. نويسنده , , Messer، Roland نويسنده , , Pelle، Xavier نويسنده , , Lehmann، Hansjorg نويسنده , , Zimmermann، Jurg نويسنده , , Haner، Robert نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
-2440
From page
2441
To page
0
Abstract
The synthesis of natural product-like compounds on solid support is described. Starting from a readily accessible D-(-)ribose derivative, a tricyclic scaffold is prepared in five steps. After coupling onto solid supports bearing different substituents (PAL resins), the scaffold can be further derivatised at two diversity points. Representative derivatives obtained by this diversity-oriented procedure are described.
Keywords
solid-phase synthesis , hetero Diels-Alder reactions , Furans , medicinal chemistry , combinatorial
Journal title
Synlett
Serial Year
2005
Journal title
Synlett
Record number
110829
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