Title of article
Direct Acylation across a Silyloxy System of Glycerol with Carboxylic Acid Anhydrides: A Novel Strategy to the Prodrug Carrier Modules - 1,3-Diacyl-sn-glycerols
Author/Authors
Stamatov، Stephan D. نويسنده , , Stawinski، Jacek نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
-2586
From page
2587
To page
0
Abstract
Trichloroacetylation of 1-acyl-3-O-tert-butyldimethylsilyl-sn-glycerols, followed by a direct conversion of the silyl protecting group into an ester functionality by means of a reagent system: tetra-n-butylammonium bromide (TBABr)-trimethylsilyl bromide (TMSBr)-carboxylic acid anhydride (CAA), constitutes an efficient protocol for the preparation of enantiomerically pure 1,3-diacyl-sn-glycerols in high yields.
Keywords
structured triglycerides , prodrug carriers , tetra-n-butylammonium bromide , trimethylsilyl bromide , silyl protections , 1,3-diacyl-sn-glycerols , carboxylic acid anhydrides
Journal title
Synlett
Serial Year
2005
Journal title
Synlett
Record number
110861
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