Title of article :
Liquid-Phase Traceless Synthesis of 3,5-Disubstituted 1,2,4-Triazoles
Author/Authors :
Wang، Jun-Ke نويسنده , , Zong، Ying-Xiao نويسنده , , Wang، Xi-Cun نويسنده , , Wu، Dong-Qing نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2005
Abstract :
A liquid-phase traceless route to 3,5-disubstituted-1,2,4-triazoles has been developed, which allows for the incorporation of two elements of diversity. The heterocycle was constructed upon PEG6000 (soluble polymer) modified by 4-hydroxy-2methoxybenzaldehyde, from which a traceless cleavage could be realized with TFA-CH2Cl2. This method provided a library of 3,5-disubstituted-1,2,4-triazoles with high yields and purity.
Keywords :
Lawesson’s reagent , cyclization reaction , 1,2,4-triazoles , soluble polymer , traceless cleavage
