Title of article :
Resolution of 2-Silyloxy-1-oxiranyl-4-pentenes by HKR: Total Synthesis of (5S,7R)-Kurzilactone
Author/Authors :
Kim، Young-Ju نويسنده , , Tae، Jinsung نويسنده ,
Abstract :
Enantiomerically pure syn- and anti-2-silyloxy-1-oxiranyl-4-pentenes were prepared by using Jacobsen’s hydrolytic kinetic resolution (HKR) method. A resolved epoxypentenol generated in this fashion was used in the total synthesis of (5S,7R)kurzilactone by a pathway employing epoxide ring-opening and RCM reactions in key steps.
Keywords :
epoxides , hydrolytic kinetic resolution , kurzilactone , metathesis , total synthesis
Journal title :
Astroparticle Physics
