Title of article :
A Facile One-Pot Synthesis of Chiral (beta)-Amino Esters
Author/Authors :
Rampf، Florian A. نويسنده , , Bunlaksananusorn، Tanasri نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2005
Abstract :
We report a facile one-pot synthesis of chiral (beta)-amino esters via direct reductive amination of (beta)-keto esters with ammonium acetate (NH4OAc) and H2 in the presence of chiral Ru-ClMeOBIPHEP catalysts using 2,2,2-trifluoroethanol (TFE) as a solvent, leading to (beta)-amino esters in high yields with high enantioselectivities (up to 99% ee).
Keywords :
reductive amination , (beta)-amino esters , (beta)-keto esters , Ru-ClMeOBIPHEP catalyst
