Author/Authors :
Eghbali ، A نويسنده Pediatric Hematologist & Oncologist, Department of Pediatrics, Arak University of Medical Sciences, Arak- Iran , , Taherahmadi، H نويسنده Department of Pediatrics, Arak University of Medical Sciences, Arak- Iran , , Shahbazi، M نويسنده Student of Medicine, Arak University of Medical Sciences, Arak- Iran , , Bagheri ، B نويسنده Pharmacologist, Department of pharmacology, Semnan University of Medical Sciences, Semnan-Iran , , Ebrahimi ، L نويسنده Blood transfusion research center, High Institute for Research and Education in Transfusion Medicine, Tehran-Iran ,
Abstract :
Background
Frequent blood transfusion is often associated with iron overload. Proper use of iron chelators to treat iron overload requires an accurate measurement of iron levels. Magnetic resonance T2-star (T2* MRI) can measure iron level in the heart and liver. Our goal was to see whether an association exists between serum ferritin level and T2* MRI in patients with major beta thalassemia.
Materials and Methods
Sixty patients with a diagnosis of major beta thalassemia were enrolled in the study. They were older than five years old and needed regular transfusion.
Cardiac and hepatic T2*MRI and mean serum ferritin levels were measured within 3 months.
Results
No significant correlation was observed between serum ferritin level and cardiac T2*MRI (p=0.361, r=-0.120).However, a significant correlation was observed between serum ferritin and liver T2*MRI (p=0.021, r=-0.297).
Conclusion
Our results showed an association between hepatic T2*MRI and serum ferritin level.
