• Title of article

    Isolation of Intermediary anti-Aldol Adducts of the Horner-Wadsworth-­Emmons Reaction Utilizing Direct Titanium-Aldol Addition and Successive Br?nsted Acid Promoted Stereoselective Elimination Leading to (Z)-(alpha),?-Unsaturated Esters

  • Author/Authors

    Misaki، Tomonori نويسنده , , Tanabe، Yoo نويسنده , , Katayama، Mayumi نويسنده , , Nagase، Ryohei نويسنده , , Mitarai، Kumi نويسنده ,

  • Pages
    -128
  • From page
    129
  • To page
    0
  • Abstract
    The reagent TiCl4-Et3N was used in the Horner-Wadsworth-Emmons (HWE)-type reaction of triethylphosphonocarboxylates with aldehydes, wherein unstable intermediary aldol adducts were isolated with anti-selectivity. Subsequent Br?nsted acid promoted stereoselective elimination was successfully performed using TBS-benzamide-pyridinium triflate to give the lessaccessible Z-(alpha),?-unsaturated esters
  • Keywords
    Ti-aldol addition , stereoselective , silylbenzamide , Z-alkenes , Horner-Wadsworth-Emmons reaction
  • Journal title
    Astroparticle Physics
  • Record number

    110920

    • Link To Document
    https://search.isc.ac/dl/search/defaultta.aspx?DTC=10&DC=110920