Synthesis and Reaction of the First Oxazol-4-ylboronates: Useful Reagents for the Preparation of the Oxazole-Containing Biaryl Compounds

The first oxazol-4-ylboronates were prepared from the corresponding 4-bromo- and 4-trifluoromethanesulfonyloxy-oxazoles. The Suzuki coupling using the resulting boron reagents with various aryl halides, including benzene, pyridine, oxazole and thiazole rings, in the presence of palladium catalyst proceeded to produce the oxazole-containing biaryl compounds in moderate to good yields.