Title of article :
Stereoselective Synthesis of a Potent Human NK1 Receptor Antagonist via Acyl-Claisen Rearrangement
Author/Authors :
Raubo، Piotr نويسنده , , Giuliano، Claudio نويسنده , , Hill، Alastair W. نويسنده , , Huscroft، Ian T. نويسنده , , London، Clare نويسنده , , Reeve، Austin نويسنده , , Seward، Eileen M. نويسنده , , Swain، Christopher G. نويسنده , , Kulagowski، Janusz J. نويسنده ,
Pages :
-5
From page :
6
To page :
0
Abstract :
Stereoselective synthesis of the tetrahydropyran derivative 1 is reported. Diastereoselective acyl-Claisen rearrangement was employed for formation of C3 and C4 chiral centres on the ­tetrahydropyran ring.
Keywords :
acyl-Claisen rearrangement , asymmetric synthesis , ­total synthesis , Stereoselectivity , NK1 receptors
Journal title :
Astroparticle Physics
Record number :
110997
Link To Document :
https://search.isc.ac/dl/search/defaultta.aspx?DTC=10&DC=110997
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