Title of article
A Generic and Reproducible Route to Homo- and Heteroannular Bicyclic (beta)-Diketones via Knochel-Type 1,4-Conjugate Additions to (alpha),(beta)-Unsaturated Cycloalkenones
Author/Authors
McGRATH، MATTHEW نويسنده , , Hill، Cheryl L. نويسنده , , Hunt، T. نويسنده , , Grogan، Gideon نويسنده ,
Pages
-308
From page
309
To page
0
Abstract
A generic and reproducible method for the preparation of homo- and heteroannular bicyclic (beta)-diketones is reported. The method employs the copper acetate mediated 1,4-conjugate addition of organozinc derivatives of iodopropionate and iodobutanoate esters to (alpha),(beta)-unsaturated cycloalkenones, followed by intramolecular Dieckmann condensation.
Keywords
bicyclic compounds , cyclisations , enzymes , annulation , ketones
Journal title
Astroparticle Physics
Record number
111040
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