Title of article :
Synthesis of Carbocyclic Pyrimidine Nucleosides Using the Mitsunobu Reaction - Part II: Influence of the Solvent on N1versus O^2-Alkylation
Author/Authors :
Ludek، Olaf R. نويسنده , , Meier، Chris نويسنده ,
Abstract :
The influence of the solvent on N- vs O-alkylation of N3-benzoylthymine under Mitsunobu conditions is described. The Mitsunobu reaction is an important tool in carbocyclic nucleoside chemistry for the direct coupling of alcohols with heterocyclic bases under mild conditions.
Keywords :
antiviral agents , medicinal chemistry , carbocyclic nucleosides , regioselectivity , Mitsunobu reaction
Journal title :
Astroparticle Physics
